| Sat 27-Aug-2022 |
|---|
| 15:00 | Dundonald Bluebell | 3‑1 | Tayport | |
| 15:00 | Fort William | 0‑4 | Benburb | |
| 15:00 | Haddington Athletic | 1‑3 | Darvel | |
| 15:00 | Invergordon | 1‑5 | Newtongrange Star | |
| 15:00 | Irvine Meadow | 1‑1 | Hill Of Beath Hawthorn | |
| 15:00 | Linlithgow Rose | 9‑0 | St. Cuthbert Wanderers | |
| 15:00 | Pollok | 6‑0 | Girvan | |
| 15:00 | Preston Athletic | 0‑1 | Newton Stewart | |
| 15:00 | Sauchie Juniors | 4‑2 | St Andrews United | |
| 15:00 | Vale of Leithen | 0‑2 | Dunbar United | |
| 15:00 | Wigtown & Bladnoch | 0‑12 | Dunipace | |
| 14:30 | Drumchapel United | 3‑0 | Easthouses Lily | |
| 14:30 | Penicuik Athletic | 0‑1 | Musselburgh Athletic | |
| 14:30 | Whitehill Welfare | 1‑4 | Camelon Juniors | |
| 14:00 | Clydebank | 4‑1 | Bonnyton Thistle | |
