| Sun 05-Dec-2021 |
|---|
| 14:00 | Wolverhampton Women | 0‑4 | Nott'm Forest Women| | |
| 13:00 | Chorley Women | 5‑0 | Bradford W | |
| 13:00 | Ipswich Women | 4‑0 | Crawley Women | |
| 13:00 | Leafield Athletic | 2‑3 | Lincoln City Women | |
| 13:00 | Lye Town W | 1‑2 | Northampton W | |
| 13:00 | Norton & Stockton W | 1‑2 | Leeds Women | |
| Sun 28-Nov-2021 |
|---|
| 15:00 | Ashford Town W | 3‑0 | Oxford Utd Women | |
| 14:00 | Cambridge City W | 1‑2 | Stourbridge W | |
| 14:00 | Eastleigh Community | 0‑5 | Exeter City W | |
| 14:00 | Portsmouth Women | 2‑1 | Bournemouth W | |
| 14:00 | Stevenage W | 0‑2 | Loughborough W | |
| 13:15 | QPR Women | 0‑3 | Billericay Town Women | |
| 13:00 | AFC Fylde Women | 2‑3 | Burnley Women | |
| 13:00 | Chichester & Selsey W | 0‑3 | Bridgwater United | |
| 13:00 | Gillingham Women | 2‑0 | Actonians W | |
